Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
ST2L expression was increased in severe asthma (P = .02) and associated with multiple indicators of TH2-like inflammation, including blood eosinophils (P = .001), exhaled nitric oxide (P = .003), and epithelial CLCA1 (P < .0001) and eotaxin-3 (P = .001) mRNA expression.
|
25091434 |
2015 |
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We assessed in the prospective birth cohort Prevention and Incidence of Asthma and Mite Allergy (PIAMA) whether IL1RL1 SNPs associate with levels of its soluble transcript IL1RL1 (IL1RL1-a) in serum, blood eosinophil counts, and asthma prevalence from birth to age 8 years, and whether IL1RL1-a serum levels associate with blood eosinophil counts.
|
21281963 |
2011 |
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Plasma and sputum IL-33, soluble ST2 (sST2) levels, and ST2L expression on eosinophils were measured in 10 healthy controls and 10 allergic asthmatics.
|
29694974 |
2018 |
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Modulation of ILC2 function by miR-146a may depend on IL-33/interleukin 1 receptor-like 1 (IL1RL1 or ST2) signaling through inhibiting IRAK1 and TRAF6.miR-146a can inhibit IRAK1 and TRAF6, downstream molecules of ST2 signal pathway, thereby negatively regulate IL-33/ST2-activated ILC2 to inhibit asthma.
|
31435003 |
2020 |
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Lung ST2L and toll-like receptor 9 protein expression levels concomitantly increased in a time-dependent manner during fungal asthma.
|
21640974 |
2011 |
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
IL1RL1-a levels negatively correlated with blood eosinophil counts, whereas there was no association between IL1RL1-a levels and asthma.In conclusion, asthma-associated <i>IL1RL1</i> SNPs strongly regulate <i>IL1RL1</i> methylation and serum IL1RL1-a levels, yet neither these <i>IL1RL1-</i>methylation CpG sites nor IL1RL1-a levels are associated with asthma.
|
29519908 |
2018 |
Asthma
|
0.500 |
Biomarker
|
disease |
CTD_human |
Four of these, GSDMB, IL33, RAD50 and IL1RL1, were previously reported as asthma susceptibility loci, but the effect sizes for these loci in our cohort were considerably larger than in the previous genome-wide association studies of asthma.
|
24241537 |
2014 |
Asthma
|
0.500 |
Biomarker
|
disease |
CTD_human |
Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups.
|
21804549 |
2011 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
IL-33 is likely to play a critical role in asthma because the IL33 and ST2/IL1RL1 genes have been reproducibly identified as major susceptibility loci in large-scale genome-wide association studies.
|
25313073 |
2014 |
Asthma
|
0.500 |
Biomarker
|
disease |
LHGDN |
Association of IL1RL1, IL18R1, and IL18RAP gene cluster polymorphisms with asthma and atopy.
|
18774397 |
2008 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups.
|
21804549 |
2011 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Multimarker analysis identified TGFB1, IL1RL1, the gene encoding IL-18 receptor 1 (IL18R1), and DPP10 as the genes most significantly associated with asthma.
|
19910030 |
2010 |
Asthma
|
0.500 |
Biomarker
|
disease |
CTD_human |
IL-33 Drives Augmented Responses to Ozone in Obese Mice.
|
27472835 |
2017 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
TH2 pathway genes (IL13, TSLP, IL33, and IL1RL1) conferring asthma susceptibility were not associated with lung function.
|
23541324 |
2013 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Four of these, GSDMB, IL33, RAD50 and IL1RL1, were previously reported as asthma susceptibility loci, but the effect sizes for these loci in our cohort were considerably larger than in the previous genome-wide association studies of asthma.
|
24241537 |
2014 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Several genes in the TLR-related pathway were associated with atopy and/or asthma [e.g.IL1RL1, BPI, NOD1, NOD2 and MAP3K7IP1].
|
19968634 |
2010 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Clinical and genetic studies indicate that IL1RL1 plays an important role in the development and exacerbations of asthma.
|
22574108 |
2012 |
Asthma
|
0.500 |
Biomarker
|
disease |
CTD_human |
A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls).
|
19198610 |
2009 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
This study aimed to characterize DNA methylation (DNA-me) in promoter region of IL33, IL1RL1 and CCL26 in asthma and their impacts on transcriptional activity in bronchial epithelial cells (BECs).
|
30468398 |
2018 |
Asthma
|
0.500 |
Biomarker
|
disease |
CTD_human |
However, a variant in IL1RL1 that is in low linkage disequilibrium with that reported previously was associated with asthma risk after accounting for all variants tested (rs10197862, gene wide P = 0.01).
|
21150878 |
2011 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
We uncovered several promising tissue-specific regulatory TFs or genes for Alzheimer's disease (e.g.ZIC1 and STX1B) and asthma (e.g.CSF3 and IL1RL1).
|
29378629 |
2018 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genome-wide association studies have begun to identify genes underlying asthma (e.g., IL1RL1), which represent future therapeutic targets.
|
22455494 |
2012 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Associations with variation in genes encoding the epithelial cell-derived cytokines, interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP), and the IL1RL1 gene encoding the IL-33 receptor, ST2, highlight the central roles for innate immune response pathways that promote the activation and differentiation of T-helper 2 cells in the pathogenesis of both asthma and allergic diseases.
|
21682736 |
2011 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Identification of a new locus at 16q12 associated with time to asthma onset.
|
27130862 |
2016 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls).
|
19198610 |
2009 |